ceesdekker.net - An Overview

ceesdekker.net - An Overview

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2009, discovery of a fresh phenotype for bacteria in narrow nanofluidic slits; and very first detection of regional protein constructions alongside DNA employing reliable-condition nanopores

1996, to start with mesoscopic charge density waves products; and first electrical measurements on an individual metallic nanocluster in between nanoelectrodes

Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins

Non-equilibrium folding of individual DNA molecules recaptured up to 1000 times in a solid state nanopore

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Microbiology has only been around to get a century, considering that we began to review micro-organisms extra significantly. I believed nanobiology was an correct expression, mainly because all molecular Organic relevant interactions occur on the nanoscale: a protein is some nanometres in size, DNA is 2 nm thick.’

All parameters have been a similar for every panel Within this video clip, except for the Preliminary placement on the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early as a consequence of translocation of your rod with the pore are marked by a grey track record.

Studying DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

‘Indeed, I understand men and women were amazed at the time. At the conclusion of the nineties, when I was in my forties, I used to be Professor of Molecular Electronics and I've to admit that it experienced turn into a bit bored, I didn’t understand much any more. The sector went more into the appliance aspect, how you could combine nanotubes into Digital circuits.

There was a single issue though — we didn't observe any measurable electrical conduction from the single polymer molecules. We concluded that at the single-molecule level, conducting polymers had been basically not this kind of excellent conductors, which was instead disappointing. We So broadened our watch to try to uncover additional promising molecules.

Example (four) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is shown in grey, the rim of your pore is highlighted in red, and also a 3D rendering of the motion on the DNA rod is exhibited.

Cees Dekker ceesdekker is Distinguished College Professor at TU Delft. Trained being a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes while in the nineteen nineties. Considering that 2000, he moved to one-molecule biophysics and nanobiology. His present exploration concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, especially SMC motor protein; and (iii) building a living artificial mobile from lifeless molecules. Dekker is definitely an elected member of your KNAW and fellow towards the APS along with the IOP.

Developments in nanotechnology during the 1990s made creating Digital devices from single molecules a probability. Cees Dekker recounts how his team produced a area-temperature transistor dependant on a single carbon nanotube.

2004, discovery of latest physics in translocation of DNA by means of nanopores; first experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual solitary-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of the mechanical Houses of double-stranded RNA; and initial one-molecule research of DNA translocation by a restriction-modification enzyme.